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In the United States, this led to the Tobacco Master Settlement Agreement, which settled the lawsuit in exchange for a combination of yearly payments to the states and voluntary restrictions on advertising and marketing of tobacco products.
In the 1970s, Brown & Williamson cross-bred a strain of tobacco to produce Y1.
The astronomer Thomas Harriot, who accompanied Sir Richard Grenville on his 1585 expedition to Roanoke Island, explains that the plant "openeth all the pores and passages of the body" so that the natives’ "bodies are notably preserved in health, and know not many grievous diseases, wherewithall we in England are often times afflicted." In the late 19th century, cigarettes became popular.
In the 1990s, this prompted the Food and Drug Administration to use this strain as evidence that tobacco companies were intentionally manipulating the nicotine content of cigarettes.These seeds were planted in the outskirts of Toledo, more specifically in an area known as "Los Cigarrales" named after the continuous plagues of cicadas (cigarras in Spanish).